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Rocaglamide | TNFalpha inhibitor

Rocaglamide (84573-16-0) is a potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200nM.1  It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and TNF-α production at 50nM in T-cells without inhibiting AP-1 and NF-κB (conversely, at concentrations <100nM, it was shown to increase NF-κB activity).2  Immunosuppression activity was due to inhibition of cytokine gene expression via blocking of NF-AT activity and is a different mechanism than suppression via Cyclosporine A and FK-506. Rocaglamide has anti-cancer properties via various pathways including ERK inhibition3, ATM/ATR-Chk1/Chk2 activation4, and p38 and JNK activation5.


1) Baumann et al. (2002), Rocaglamide Derivatives Are Potent Inhibitors of NF-kB Activation in T-cells; J. Biol. Chem. 277 44791
2) Prolsch et al. (2005), Rocaglamide Derivativews Are Immunosuppressive Phytochemicals That Target NF-AT Activity in T Cells; J. Immunol. 174 7075
3) Polier et al. (2012), The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin1 and 2; Chem. Biol. 19 1093
4) Neumann et al. (2014), The natural anticancer compound rocaglamide selectively inhibits the G1-S phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints; Int. J. Cancer 134 1991
5) Zhu et al. (2007), The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities; Int. J. Cancer 121 1839

Focus Biomolecules cell signaling reagent supplier, chemical structure of Rocaglamide | NFkB inhibitor | CAS 84573-16-0

Catalog#  10-2484-0100

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Catalog Number:
TNFalpha inhibitor
Molecular Weight:
Molecular Formula:
Soluble in DMSO or Ethanol
Physical Properties:
White solid supplied as a thin film on vial.
97% by HPLC
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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