Rofecoxib | Selective COX-2 inhibitor

CAS:
162011-90-7
Catalog Number:
10-2440
Activity:
Selective COX-2 inhibitor
Alternate Names:
MK-966
Chemical Name:
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Molecular Weight:
314.36
Molecular Formula:
C17H14O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
50 mg$65.00
250 mg$250.00

Rofecoxib (162011-90-7) is a potent and selective COX-2 inhibitor with 1000-fold selectivity over COX-1, IC50=26 nm vs >50 μM.1 Potent nonsteroidal anti-inflammatory agent.1 Rofecoxib was a clinically useful NSAID until it was withdrawn from use due to cardiovascular side effects.2

References/Citations:

1) Chan et al. (1999), Rofecoxib [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles; J. Pharmacol. Exp. Ther., 290 551
2) Catalla-Lawson et al. (2013), Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics and vasoactive eicosanoids; J. Pharmacol. Exp. Ther., 289 735

CAS:
162011-90-7
Catalog Number:
10-2440
Activity:
Selective COX-2 inhibitor
Alternate Names:
MK-966
Chemical Name:
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Molecular Weight:
314.36
Molecular Formula:
C17H14O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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