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Product Details

Romidepsin | HDAC inhibitor

Romidepsin (128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively.1 Induces apoptosis in a variety of cell lines2 and displays antitumor activity in mouse models3. Romidepsin was recently approved for clinical use in T-cell lymphoma.4

1) Furumai et al. (2002), FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases; Cancer Res., 62 4916
2) Panicker et al. (2010), Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells; Cell Cycle, 9 1830
3) Ueda et al. (1994), FR901228, a novel anti-tumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice; J. Antibiot. (Tokyo), 47 315
4) VanderMolin et al. (2011), Romodepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma; J. Antibiotic. (Tokyo), 64 525

Focus Biomolecules cell signaling reagent supplier, chemical structure of Romidepsin | HDAC inhibitor | CAS 128517-07-7

Catalog#  10-2365-0001

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
HDAC inhibitor
Alternate Names:
FK228, FR901228, Depsipeptide
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Colorless waxy solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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