Rotenone | Mitochondrial Complex I Inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 50 mg | $48.00 | ||
| 1 g | $80.00 |
Rotenone (83-79-4), the most common member of the rotenoid natural product family, inhibits complex I of the mitochondrial electron transport chain (IC50 = 1.7 – 2.2 μM).1 Also inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM).2 May be used to induce Parkinsonism in animal models.3,4 Inhibits autophagy by blocking lysosomal degradation of autophagic vacuoles.5
References/Citations:
- Heinz et al. (2017), Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation; Sci. Rep., 7 45465
- Cherednichenko et al. (2004), NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release; Circ. Res., 94 478
- Uversky (2003), Neurotoxicant-induced animal models of Parkinson’s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration; Cell Tissue Res., 318 225
- Zheng et al. (2023), LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson’s Cell Model; Int. J. Mol. Sci., 24 11111
- Mader et al. (2012), Rotenone inhibits autophagic flux prior to inducing cell death; ACS Chem. Neurosci., 3 1063
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Rotenone (83-79-4), the most common member of the rotenoid natural product family, inhibits complex I of the mitochondrial electron transport chain (IC50 = 1.7 – 2.2 μM).1 Also inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM).2 May be used to induce Parkinsonism in animal models.3,4 Inhibits autophagy by blocking lysosomal degradation of autophagic vacuoles.5
References/Citations:
- Heinz et al. (2017), Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation; Sci. Rep., 7 45465
- Cherednichenko et al. (2004), NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release; Circ. Res., 94 478
- Uversky (2003), Neurotoxicant-induced animal models of Parkinson’s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration; Cell Tissue Res., 318 225
- Zheng et al. (2023), LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson’s Cell Model; Int. J. Mol. Sci., 24 11111
- Mader et al. (2012), Rotenone inhibits autophagic flux prior to inducing cell death; ACS Chem. Neurosci., 3 1063
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1-855-FOCUS21
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