Rucaparib phosphate | PARP1 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $280.00 |
Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2 Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3 Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel,3 and temozolomide.4 Ameliorates the cardiotoxicity of doxorubicin.5 Recently approved for human use by the FDA.
References/Citations:
1) Thomas et al. (2007), Preclinical selection of a n novel poly(ADP-ribose) polymerase inhibitor for clinical trial; Mol. Cancer Ther., 6 945
2) Drew et al. (2011), Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2; J. Natl. Cancer Inst., 103 334
3) Ihnen et al. (2013), Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer; Mol. Cancer Ther., 12 1002
4) Plummer et al. (2013), A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation; Cancer Chemother. Pharmacol., 71 1191
5) Ali et al. (2011), The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice; Mol. Cancer Ther., 10 2320
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2 Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3 Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel,3 and temozolomide.4 Ameliorates the cardiotoxicity of doxorubicin.5 Recently approved for human use by the FDA.
References/Citations:
1) Thomas et al. (2007), Preclinical selection of a n novel poly(ADP-ribose) polymerase inhibitor for clinical trial; Mol. Cancer Ther., 6 945
2) Drew et al. (2011), Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2; J. Natl. Cancer Inst., 103 334
3) Ihnen et al. (2013), Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer; Mol. Cancer Ther., 12 1002
4) Plummer et al. (2013), A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation; Cancer Chemother. Pharmacol., 71 1191
5) Ali et al. (2011), The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice; Mol. Cancer Ther., 10 2320
Related products
-
BI 2536 | Dual Plk/BRD4 inhibitor – Destabilizes Myc
From $75.00CAS:755038-02-9Catalog Number:10-4121Activity:Dual Plk/BRD4 inhibitor – Destabilizes MycChemical Name:4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamideMolecular Weight:521.67Molecular Formula:C28H39N7O3Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)Physical Properties:Off-white solidPurity:97% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
N-Eicosanoyl serotonin | Neuroprotective
From $50.00Catalog Number:10-3631Activity:NeuroprotectiveChemical Name:Eicosanoyl-5-hydroxytryptamideAlternate Name:Eicosanoyl serotonin, EHTMolecular Weight:470.73Molecular Formula:C30H50N2O2Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase supplied. Protect from air. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
Levetiracetam | Anticonvulsant
From $45.00CAS:102767-28-2Catalog Number:10-2040Activity:AnticonvulsantChemical Name:2(S)-(2-Oxopyrrolidin-1-yl)butyramideMolecular Weight:170.21Molecular Formula:C29H14N2O2Solubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
