RVX-208 | BET bromodomain inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $68.00 | ||
| 25 mg | $272.00 |
RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD1.1,2 RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in vivo.3 Reduces atherosclerosis.4
References/Citations:
1) Picaud et al. (2013), RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain; Proc. Natl. Acad. Sci. USA, 110 19754
2) McLure et al. (2013), RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist; PLoS One, 8e83190
3) Bailey et al. (2010), RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; J. Am. Coll. Cardiol., 55 2580
4) Jahagirdar et al. (2014), A novel BET bromodomain inhibitor, RVX-208 shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice; Atherosclerosis, 236 91
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD1.1,2 RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in vivo.3 Reduces atherosclerosis.4
References/Citations:
1) Picaud et al. (2013), RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain; Proc. Natl. Acad. Sci. USA, 110 19754
2) McLure et al. (2013), RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist; PLoS One, 8e83190
3) Bailey et al. (2010), RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; J. Am. Coll. Cardiol., 55 2580
4) Jahagirdar et al. (2014), A novel BET bromodomain inhibitor, RVX-208 shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice; Atherosclerosis, 236 91
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