S-Trityl-cysteine | Kinesin Eg5 inhibitor

CAS:
2799-07-7
Catalog Number:
10-1042
Activity:
Kinesin Eg5 inhibitor
Chemical Name:
(+)-S-Trityl-L-cysteine
Molecular Weight:
363.47
Molecular Formula:
C22H21NO2S
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
1 gram$35.00

S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines.

References/Citations:

1) DeBonis et al. (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities; Mol. Cancer Ther. 3 1079
2) Brier et al. (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5; Biochemistry 43 13072
3) Skoufias et al. (2006) S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression; J. Biol. Chem., 281 17559

CAS:
2799-07-7
Catalog Number:
10-1042
Activity:
Kinesin Eg5 inhibitor
Chemical Name:
(+)-S-Trityl-L-cysteine
Molecular Weight:
363.47
Molecular Formula:
C22H21NO2S
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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