Salinomycin Na | Cancer stem cell inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $40.00 | ||
| 25 mg | $100.00 |
Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1 Salinomycin Na displays selective toxicity for cancer stem cells.1 Induces rapid mitochondrial hyperpolarization.2 Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3 Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4 Kills cancer stem cells by sequestering iron.5
References/Citations:
1) Gupta et al. (2009), Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell, 138 645
2) Manago et al. (2015), Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis., 6 e1930
3) Fu et al. (2016), Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway; Oncol. Rep., 35 912
4) Kim et al. (2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin; Mol. Med. Rep., 12(2) 1898
5) Mai et al. (2017) Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem., 9 1025
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1 Salinomycin Na displays selective toxicity for cancer stem cells.1 Induces rapid mitochondrial hyperpolarization.2 Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3 Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4 Kills cancer stem cells by sequestering iron.5
References/Citations:
1) Gupta et al. (2009), Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell, 138 645
2) Manago et al. (2015), Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis., 6 e1930
3) Fu et al. (2016), Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway; Oncol. Rep., 35 912
4) Kim et al. (2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin; Mol. Med. Rep., 12(2) 1898
5) Mai et al. (2017) Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem., 9 1025
Related products
-
Daptomycin | Antibiotic
From $50.00CAS:103060-53-3Catalog Number:10-2692Activity:AntibioticAlternate Names:Cubicin; LY146032Molecular Weight:1620.71Molecular Formula:C72H101N17O26Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 50 mg/ml).Physical Properties:Pale yellow solidPurity:95% by HPLCStorage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Blasticidin S HCl | Antibiotic selection agent
From $80.00CAS:3513-03-9Catalog Number:10-2830Activity:Blasticidin S HClChemical Name:(S)-4-[[3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-hex-2-enopyranuronic acid hydrochlorideMolecular Weight:458.90Molecular Formula:C17H26N8O5 &bul; HClSolubility:Soluble in Water (greater than 25 mg/ml)Physical Properties:White solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT -
Thiostrepton | Antibiotic and FOXM1 inhibitor
From $85.00CAS:1393-48-2Catalog Number:10-2108Activity:Antibiotic and FOXM1 inhibitorChemical Name:Fermentation product from Streptomyces azureusMolecular Weight:1664.91Molecular Formula:C72H85N19O185Solubility:Soluble in DMSO (up to 15 mg/ml), or in Chloroform (up to 5 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC and HPLCStorage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
