Santacruzamate A | Ultrapotent HDAC2 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $46.00 | ||
| 25 mg | $166.00 |
Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1 Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2 Potential therapeutic agent for breast cancer.3 Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4 Ameliorates Alzheimer’s disease-like pathology in mouse models.4
References/Citations:
1) Pavlik et al. (2013), Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod., 76 2026
2) Zhou et al. (2018), Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif., 51(3) e12447
3) Damaskos et al. (2017), Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer; Anticancer Res., 37 35
4) Chen et al. (2019), Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro; Front. Cell. Neurosci., 13 61
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1 Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2 Potential therapeutic agent for breast cancer.3 Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4 Ameliorates Alzheimer’s disease-like pathology in mouse models.4
References/Citations:
1) Pavlik et al. (2013), Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod., 76 2026
2) Zhou et al. (2018), Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif., 51(3) e12447
3) Damaskos et al. (2017), Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer; Anticancer Res., 37 35
4) Chen et al. (2019), Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro; Front. Cell. Neurosci., 13 61
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