SC-51089 | Prostaglandin E2 (EP1) antagonist

CAS:
146033-02-5
Catalog Number:
10-1135
Activity:
PGE2 (EP1 receptor) antagonist
Chemical Names:
8-Chlorodibenz(Z)[b,f]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride
Molecular Weight:
459.34
Molecular Formula:
C22H19ClN4O3·HCl
Solubility:
Soluble in DMSO (25 mg/ml) or water (25 mg/mL)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$55.00
25 mg$220.00

SC-51089 (146033-02-5) is a prostaglandin E2 (EP1 receptor) antagonist (pA2=6.5, guinea pig ileum muscle strip assay )1,4. Possesses analgesic activity in vivo (rodent ED50= 6.8 mg/kg)1,2,4. SC-51089 does not inhibit COX11 and does not block PGE1 induced hyperalgesia3.

References/Citations:

1) Hallinan et al. (1993), N-substituted dibenzoxazepines as analgesic PGE2 antagonists; J. Med. Chem., 36
2) Malmberg et al. (1994), Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on rat; Neurosci. Lett., 173 193
3) Khasar et al. (1994), Comparison of prostaglandin E1- and prostaglandin E2 hyperalgesia in the rat; Neuroscience, 62 345
4) Hallinan et al. (1996), Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs; J. Med. Chem., 39 609

CAS:
146033-02-5
Catalog Number:
10-1135
Activity:
PGE2 (EP1 receptor) antagonist
Chemical Names:
8-Chlorodibenz(Z)[b,f]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride
Molecular Weight:
459.34
Molecular Formula:
C22H19ClN4O3·HCl
Solubility:
Soluble in DMSO (25 mg/ml) or water (25 mg/mL)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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