SC-514 | IKK-2 inhibitor

CAS:
354812-17-2
Catalog Number:
10-1054
Activity:
IKK-2 inhibitor
Chemical Name:
5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
Molecular Weight:
224.3
Molecular Formula:
C9H8N2OS2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$65.00
50 mg$260.00

SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1

References/Citations:

1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861

CAS:
354812-17-2
Catalog Number:
10-1054
Activity:
IKK-2 inhibitor
Chemical Name:
5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
Molecular Weight:
224.3
Molecular Formula:
C9H8N2OS2
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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