SC-560 | Selective COX-1 inhibitor

CAS:
18817-13-2
Catalog Number:
10-2531
Activity:
Selective COX-1 inhibitor
Chemical Name:
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Molecular Weight:
352.74
Molecular Formula:
C17H12ClF3N2O
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Brown solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

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This product is also available in the following library:
Cancer Cell Metabolism Library

SC-560 (188817-13-2) is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNF α-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.2

References/Citations:

1) Smith et al. (1998), Pharmacological analysis of cyclooxygenase-1 in inflammation; Proc. Natl. Acad. Sci. USA 95 13313
2) Brenneis et al. (2006), Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition; FASEB J. 20 1352

CAS:
18817-13-2
Catalog Number:
10-2531
Activity:
Selective COX-1 inhibitor
Chemical Name:
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Molecular Weight:
352.74
Molecular Formula:
C17H12ClF3N2O
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Brown solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

SC-560 (188817-13-2) is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNF α-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.2

References/Citations:

1) Smith et al. (1998), Pharmacological analysis of cyclooxygenase-1 in inflammation; Proc. Natl. Acad. Sci. USA 95 13313
2) Brenneis et al. (2006), Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition; FASEB J. 20 1352

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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

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Plymouth Meeting, PA USA
1-855-FOCUS21

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