SC-79 | AKT activator
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $130.00 |
SC-79 (305834-79-1) is an Akt activator. It binds to the pleckstrin homology domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. SC-79 enhances Akt phosphorylation by upstream protein kinases. It suppresses excitotoxicity-induced neuronal death in vitro and in vivo.1 A useful tool for studying the PI3K/Akt axis.2
References/Citations:
1) Jo et al. (2012), Small-molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death; Proc. Natl. Acad. Sci. USA, 109 10581
2) Yang et al. (2016), MiR-221 Promotes Capan-2 Pancreatic Ductal Adenocarcinoma Cells Proliferation by Targeting PTEN-Akt; Cell. Physiol. Biochem. 38 2366
3) Chen et al. (2017), Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head; Oncotarget, 8 31065
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SC-79 (305834-79-1) is an Akt activator. It binds to the pleckstrin homology domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. SC-79 enhances Akt phosphorylation by upstream protein kinases. It suppresses excitotoxicity-induced neuronal death in vitro and in vivo.1 A useful tool for studying the PI3K/Akt axis.2
References/Citations:
1) Jo et al. (2012), Small-molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death; Proc. Natl. Acad. Sci. USA, 109 10581
2) Yang et al. (2016), MiR-221 Promotes Capan-2 Pancreatic Ductal Adenocarcinoma Cells Proliferation by Targeting PTEN-Akt; Cell. Physiol. Biochem. 38 2366
3) Chen et al. (2017), Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head; Oncotarget, 8 31065
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