SCH-202676 | G-protein inhibitor

CAS:
265980-25-4
Catalog Number:
10-1048
Activity:
G-protein inhibitor
Chemical Name:
N-(2,3-Diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine hydrobromide
Molecular Weight:
350.28
Molecular Formula:
C15H15N3S·HBr
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$52.00
25 mg$208.00

SCH-202676 (265980-25-4) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3

References/Citations:

1) Fawzi et al. (2001), SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors; Mol.Pharmacol. 59 30
2) Lewandowicz et al. (2006), The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms; Br. J. Pharmacol. 147 422
3) Goblyos et al. (2005), Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action; J. Med. Chem., 48 1145

CAS:
265980-25-4
Catalog Number:
10-1048
Activity:
G-protein inhibitor
Chemical Name:
N-(2,3-Diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine hydrobromide
Molecular Weight:
350.28
Molecular Formula:
C15H15N3S·HBr
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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