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Product Details

SCH-202676 | G-protein inhibitor

SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50's = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3

References/Citations
1) Fawzi et al. (2001) SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors; Mol.Pharmacol. 59 30
2) Lewandowicz et al. (2006) The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms; Br..J. Pharmacol. 147 422
3) Goblyos et al. (2005) Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action; J. Med. Chem., 48 1145

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SCH-202676 | 70375-43-8 | Structure | supplier

Catalog#  10-1048

$100.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
70375-43-8
Catalog Number:
10-1048
Activity:
G-protein inhibitor
Chemical Name:
N-(2,3-Diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine hydrobromide
Molecular Weight:
350.28
Molecular Formula:
C15H16BrN3S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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