Scriptaid | HDAC inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 Mg | $75.00 | ||
| 25 Mg | $270.00 |
Scriptaid (287383-59-9) inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 μM) and HDAC8 (IC50~1 μM) and is less toxic compared to trichostatin A.1,2 Induces cell cycle arrest and epigenetic changes in colon cancer cells.3 Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic cell nuclear transfer (SCNT) embryos.4 Increases exercise endurance in mice.5
References/Citations:
1) Su et al. (2000), A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res., 60 3137
2) Huber et al. (2011), Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem., 286 22211
3) Lee et al. (2008), Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol., 33 767
4) Rissi et al. (2019), Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction, 157 123
5) Huang et al. (2020), Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol., 128 276
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Scriptaid (287383-59-9) inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 μM) and HDAC8 (IC50~1 μM) and is less toxic compared to trichostatin A.1,2 Induces cell cycle arrest and epigenetic changes in colon cancer cells.3 Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic cell nuclear transfer (SCNT) embryos.4 Increases exercise endurance in mice.5
References/Citations:
1) Su et al. (2000), A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res., 60 3137
2) Huber et al. (2011), Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem., 286 22211
3) Lee et al. (2008), Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol., 33 767
4) Rissi et al. (2019), Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction, 157 123
5) Huang et al. (2020), Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol., 128 276
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