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Product Details

Scriptaid | HDAC inhibitor

Scriptaid (287383-59-9) inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 μM) and HDAC8 (IC50~1 μM) and is less toxic compared to trichostatin A.1,2 Induces cell cycle arrest and epigenetic changes in colon cancer cells.3 Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic cell nuclear transfer (SCNT) embryos.4 Increases exercise endurance in mice.5


1) Su et al. (2000), A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res., 60 3137
2) Huber et al. (2011), Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem., 286 22211
3) Lee et al. (2008), Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol., 33 767
4) Rissi et al. (2019), Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction, 157 123
5) Huang et al. (2020), Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol., 128 276

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Catalog#  10-2712-0005

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Catalog Number:
HDAC inhibitor
Chemical Name:
Alternate Name:
Scriptide; GCK1026
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 4 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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