Selpercatinib | Potent and selective RET kinase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $45.00 | ||
| 25 mg | $150.00 |
Selpercatinib (2152628-33-4) is a potent (IC50 = 0.45 nM)1 and selective inhibitor of RET kinase.2 Clinically relevant for the treatment of RET-altered non-small cell lung cancer3 and certain thyroid cancers4.
References/Citations:
- Kooijman et al. (2022); Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020, Front. Oncol., 12 953013
- Subbiah et al. (2018), Selective RET kinase inhibition for patients with RET-altered cancers; Ann. Oncol. 29 1869
- Drilon et al. (2020); Efficacy of Selpercatinib in RET Fusion-Positive Non-Small Cell Lung Cancer, N. Engl. J. Med., 383 813
- Wirth et al. (2020); Efficacy of Selpercatinib in RET-Altered Thyroid Cancer, N. Engl. J. Med., 383 825
C29H31N7O3
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Selpercatinib (2152628-33-4) is a potent (IC50 = 0.45 nM)1 and selective inhibitor of RET kinase.2 Clinically relevant for the treatment of RET-altered non-small cell lung cancer3 and certain thyroid cancers4.
References/Citations:
- Kooijman et al. (2022); Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020, Front. Oncol., 12 953013
- Subbiah et al. (2018), Selective RET kinase inhibition for patients with RET-altered cancers; Ann. Oncol. 29 1869
- Drilon et al. (2020); Efficacy of Selpercatinib in RET Fusion-Positive Non-Small Cell Lung Cancer, N. Engl. J. Med., 383 813
- Wirth et al. (2020); Efficacy of Selpercatinib in RET-Altered Thyroid Cancer, N. Engl. J. Med., 383 825
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1-855-FOCUS21
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