Selpercatinib | Potent and selective RET kinase inhibitor
CAS:
2152628-33-4
Catalog Number:
10-4407
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $45.00 | ||
| 25 mg | $150.00 |
This product is also available in the following library:
Selpercatinib (2152628-33-4) is a potent (IC50 = 0.45 nM)1 and selective inhibitor of RET kinase.2 Clinically relevant for the treatment of RET-altered non-small cell lung cancer3 and certain thyroid cancers4.
References/Citations:
- Kooijman et al. (2022); Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020, Front. Oncol., 12 953013
- Subbiah et al. (2018), Selective RET kinase inhibition for patients with RET-altered cancers; Ann. Oncol. 29 1869
- Drilon et al. (2020); Efficacy of Selpercatinib in RET Fusion-Positive Non-Small Cell Lung Cancer, N. Engl. J. Med., 383 813
- Wirth et al. (2020); Efficacy of Selpercatinib in RET-Altered Thyroid Cancer, N. Engl. J. Med., 383 825
CAS:
2152628-33-4
Catalog Number:
10-4407
Activity:
RET kinase inhibitor
Chemical Names:
6-(2-Hydroxy-2-methylpropoxy)-4-(6-(6-((6-methyoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridine-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
Alternate Name:
LOXO-292
Molecular Weight:
525.61
Molecular Formula:
C29H31N7O3
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR: (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Selpercatinib (2152628-33-4) is a potent (IC50 = 0.45 nM)1 and selective inhibitor of RET kinase.2 Clinically relevant for the treatment of RET-altered non-small cell lung cancer3 and certain thyroid cancers4.
References/Citations:
- Kooijman et al. (2022); Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020, Front. Oncol., 12 953013
- Subbiah et al. (2018), Selective RET kinase inhibition for patients with RET-altered cancers; Ann. Oncol. 29 1869
- Drilon et al. (2020); Efficacy of Selpercatinib in RET Fusion-Positive Non-Small Cell Lung Cancer, N. Engl. J. Med., 383 813
- Wirth et al. (2020); Efficacy of Selpercatinib in RET-Altered Thyroid Cancer, N. Engl. J. Med., 383 825
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1-855-FOCUS21
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