SGC-iMLLT | MLLT1/3 YEATS domain inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $285.00 |
SGC-iMLLT (2255338-25-9) is a potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3.1 YEATS domain containing proteins bind acetyl and crotonyl marks on histone tails. Selective against the two other human YEATS domains YEATS2/4 and 48 bromodomains. YEATS containing MLL-ENL leukemic cells display increased sensitivity to SGC-iMLLT versus control AML cells.2
References/Citations:
- Moustakim et al. (2018) Discovery of an MLLT1/3 YEATS Domain Chemical Probe; Angew. Chem. Int. Eng. Ed. 57 16302
- Hu et al. (2023) The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia; Leukemia 37 190
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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SGC-iMLLT (2255338-25-9) is a potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3.1 YEATS domain containing proteins bind acetyl and crotonyl marks on histone tails. Selective against the two other human YEATS domains YEATS2/4 and 48 bromodomains. YEATS containing MLL-ENL leukemic cells display increased sensitivity to SGC-iMLLT versus control AML cells.2
References/Citations:
- Moustakim et al. (2018) Discovery of an MLLT1/3 YEATS Domain Chemical Probe; Angew. Chem. Int. Eng. Ed. 57 16302
- Hu et al. (2023) The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia; Leukemia 37 190
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