SIN-1 | Peroxynitrite Donor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $30.00 | ||
| 50 mg | $120.00 |
SIN-1 (16142-27-1) is a metabolite of molsidomine1 which spontaneously releases nitric oxide and superoxide anion which react to form peroxynitrite under physiological conditions.2 The presence of HEPES leads to the formation of hydrogen peroxide and while its absence leads to the formation of peroxynitrite.3 Inhibits platelet aggregation.4 Inhibits aggregation and toxicity of amyloid-β in cellular assays.5
References/Citations:
1) Nishikawa et al. (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites; J. Pharmacol. Exp. Ther. 220 183
2) Hogg et al. (1992) Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide; Biochem. J. 281 419
3) Kirsch et al. (1998) Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.; J. Biol. Chem. 273 12716
4) Priora et al. (2011) In vitro inhibition of human and rat platelets by NO donors nitrosoglutathione sodium nitroprusside and SIN-1 through activation of cGMP independent pathways; Pharmacol. Res. 64 289
5) Ren et al. (2017) Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor; ACS Omega. 2 243
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SIN-1 (16142-27-1) is a metabolite of molsidomine1 which spontaneously releases nitric oxide and superoxide anion which react to form peroxynitrite under physiological conditions.2 The presence of HEPES leads to the formation of hydrogen peroxide and while its absence leads to the formation of peroxynitrite.3 Inhibits platelet aggregation.4 Inhibits aggregation and toxicity of amyloid-β in cellular assays.5
References/Citations:
1) Nishikawa et al. (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites; J. Pharmacol. Exp. Ther. 220 183
2) Hogg et al. (1992) Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide; Biochem. J. 281 419
3) Kirsch et al. (1998) Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.; J. Biol. Chem. 273 12716
4) Priora et al. (2011) In vitro inhibition of human and rat platelets by NO donors nitrosoglutathione sodium nitroprusside and SIN-1 through activation of cGMP independent pathways; Pharmacol. Res. 64 289
5) Ren et al. (2017) Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor; ACS Omega. 2 243
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