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Puromycin | Translation inhibitor

Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

References/Citations
1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes; Proc. Nat. Acad. Sci. USA, 70 3866
2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation; EMBO J., 26 1385
3) Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction; Biochim. Biophys. Acta, 1150 89

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Catalog#  10-2100

$50.00
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CAS:
58-58-2
Catalog Number:
10-2100
Activity:
Translation inhibitor
Chemical Name:
(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]-amino]-3'-deoxy-N,N-dimethyl-adenosine dihydrochloride
Molecular Weight:
544.43
Molecular Formula:
C22H29N7O5 2HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
Physical Properties:
Tan solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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