SKF525A HCl | Cytochrome P450 inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 500 mg | $205.00 |
SKF-525A (62-68-0) is a commonly used non-selective Cytochrome P450 inhibitor.1 It is also a local anesthetic2 acting via blockage of the acetylcholine receptor3 – it is a commonly used reagent to stabilize the desensitized state of muscle AChR4. SKF-525A also inhibits glibenclamide-sensitive K+ channels.5
References/Citations:
1) Franklin and Hathaway (2008) 2-Diethylaminoethyl-2,2-diphenylvalerate-HCL (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol; Drug Metab. Dispos, 36 2539
2) Suarez-Kurtz and Bianchi (1970) Sites of action of SKF-525A in nerve and muscle; J. Pharmacol. Exp. Ther., 172 33
3) Spitzmaul et al. (2009) The local anesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms; Br. J. Pharmacol., 157 804
4) Prince and Sine (1999) Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models; J. Biol. Chem., 274 19623
5) Sakust and Yoneda (1994) Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes; Eur. J. Pharmacol., 252 117
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SKF-525A (62-68-0) is a commonly used non-selective Cytochrome P450 inhibitor.1 It is also a local anesthetic2 acting via blockage of the acetylcholine receptor3 – it is a commonly used reagent to stabilize the desensitized state of muscle AChR4. SKF-525A also inhibits glibenclamide-sensitive K+ channels.5
References/Citations:
1) Franklin and Hathaway (2008) 2-Diethylaminoethyl-2,2-diphenylvalerate-HCL (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol; Drug Metab. Dispos, 36 2539
2) Suarez-Kurtz and Bianchi (1970) Sites of action of SKF-525A in nerve and muscle; J. Pharmacol. Exp. Ther., 172 33
3) Spitzmaul et al. (2009) The local anesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms; Br. J. Pharmacol., 157 804
4) Prince and Sine (1999) Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models; J. Biol. Chem., 274 19623
5) Sakust and Yoneda (1994) Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes; Eur. J. Pharmacol., 252 117
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