SKPin C1 | Ubiquitin ligase E3 SCF-Skp2 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $200.00 |
SKPin C1 (432001-69-9) inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.1,2
References/Citations:
- Rico-Bautista and Wolf (2012), Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation; Chem. Biol. 19 1497
- Wu et al. (2012), Specific small molecule inhibitors of Skp2-mediated p27 degradation; Chem. Biol. 19 1515
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SKPin C1 (432001-69-9) inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.1,2
References/Citations:
- Rico-Bautista and Wolf (2012), Skipping cancer: small molecule inhibitors of SKP2-mediated p27 degradation; Chem. Biol. 19 1497
- Wu et al. (2012), Specific small molecule inhibitors of Skp2-mediated p27 degradation; Chem. Biol. 19 1515
Related products
-
Sunitinib malate | VEGFR, PDGFR kinase inhibitor
From $60.00CAS:341031-54-7Catalog Number:10-1078Activity:VEGFR, PDGFR kinase inhibitorAlternate Names:SU-11248Chemical Name:N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malateMolecular Weight:532.57Molecular Formula:C22H27FN4O4 C4H6O5Solubility:Soluble in DMSO (up to 13 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Brefeldin A | Inhibits intracellular transport
From $38.00CAS:20350-15-6Catalog Number:10-1071Activity:Inhibits intracellular transportAlternate Names:Fermentation product from Penicillium brefeldianumMolecular Weight:280.37Molecular Formula:C16H24O4Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
AAL-993 | VEGFR inhibitor
From $75.00CAS:269390-77-4Catalog Number:10-1034Activity:VEGFR inhibitorChemical Name:2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamideMolecular Weight:371.36Molecular Formula:C20H16F3N3OSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).Physical Properties:Pale yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
