SLB1122168 | Sphingosine-1-phosphate transport inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $95.00 | ||
| 25 mg | $365.00 |
SLB1122168 (2999629-17-1 ) is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
References/Citations:
- Burgio et al. (2023)2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2), J. Med. Chem., 66 5873
C22H35N3O·HCl
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SLB1122168 (2999629-17-1 ) is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
References/Citations:
- Burgio et al. (2023)2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2), J. Med. Chem., 66 5873
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