SLB1122168 | Sphingosine-1-phosphate transport inhibitor

CAS:
 2999629-17-1 |
Catalog Number:
 10-4396

Available Options

Size:PriceQuantity 
5 mg$95.00
25 mg$365.00

SLB1122168 (2999629-17-1 ) is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395).  Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.

References/Citations:

  1. Burgio et al. (2023)2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2), J.  Med. Chem., 66 5873
CAS:
2999629-17-1 |
Catalog Number:
10-4396
Activity:
Spns2 inhibitor
Chemical Names:
(S)-6-Decyl-N-(pyrrolidine-3-ylmethyl)benzo[d]oxazol-2-amine hydrochloride
Molecular Weight:
394.00
Molecular Formula:

C22H35N3O·HCl

Solubility:
Soluble in DMSO (40 mg/ml); Water (10 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!