Size: | Price | Quantity | |
---|---|---|---|
5 mg | $95.00 | ||
25 mg | $365.00 |
SLB1122168 (2999629-17-1 ) is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
References/Citations:
C22H35N3O·HCl
>98% by HPLC
NMR: (Conforms)
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SLB1122168 (2999629-17-1 ) is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but did not reduce plasma sphigosine-1-phosphate levels as with the first generation inhibitor SLF1081851 (Focus Cat# 10-4395). Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
References/Citations:
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
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