SLF1081851 | Sphingosine-1-phosphate transporter inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $90.00 | ||
| 25 mg | $345.00 |
SLF1081851 (2763730-97-6, free base) is a sphingosine-1-phosphate transporter (Spns2) inhibitor. It inhibited sphingosine-1-phosphate (S1P) release in HeLa cells: IC50 = 1.93 µM. SLF1081851 is active in vivo and decreased lymphocyte counts and plasma S1P levels in mice and rats. Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
References/Citations:
- Fritzemeier et al. (2022)Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors, J. Med. Chem., 65 7656
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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SLF1081851 (2763730-97-6, free base) is a sphingosine-1-phosphate transporter (Spns2) inhibitor. It inhibited sphingosine-1-phosphate (S1P) release in HeLa cells: IC50 = 1.93 µM. SLF1081851 is active in vivo and decreased lymphocyte counts and plasma S1P levels in mice and rats. Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.
References/Citations:
- Fritzemeier et al. (2022)Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors, J. Med. Chem., 65 7656
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