SLF1081851 | Sphingosine-1-phosphate transporter inhibitor

CAS:
2763730-97-6 (free base)
Catalog Number:
10-4395
Activity:
Sphingosine-1-phosphate transporter inhibitor
Chemical Names:
3-(3-(4-Decylphenyl)-1,2,4-oxadiazol-5-yl)propan-1-amine hydrochloride
Molecular Weight:
379.97
Molecular Formula:
C21H33N3O·HCl
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (7 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$90.00
25 mg$345.00

SLF1081851 (2763730-97-6, free base) is a sphingosine-1-phosphate transporter (Spns2) inhibitor. It inhibited sphingosine-1-phosphate (S1P) release in HeLa cells: IC50 = 1.93 µM.  SLF1081851 is active in vivo and decreased lymphocyte counts and plasma S1P levels in mice and rats.  Spns2 inhibitors represent potential alternative immunomodulatory agents to S1P receptor agonists as they are able in induce lymphopenia without drastic changes to systemic S1P levels or stimulating the S1P1-5 signaling pathway.

References/Citations:

  1. Fritzemeier et al. (2022)Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors, J. Med. Chem., 65 7656
CAS:
2763730-97-6 (free base)
Catalog Number:
10-4395
Activity:
Sphingosine-1-phosphate transporter inhibitor
Chemical Names:
3-(3-(4-Decylphenyl)-1,2,4-oxadiazol-5-yl)propan-1-amine hydrochloride
Molecular Weight:
379.97
Molecular Formula:
C21H33N3O·HCl
Solubility:
Soluble in DMSO (30 mg/ml); Ethanol (7 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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