SMED-1 | Dexamethasone sensitizer
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $180.00 |
A dexamethasone (Dex) sensitizer. SMED-1 was discovered in a screen designed to identify compounds that sensitize Dex-resistant ALL xenografts to Dex.1 The assay employed Dex-resistant ALL-19 cells which are resistant at concentrations up to 850 μM. In contrast ALL-3 cells are sensitive to nanomolar concentrations of Dex (IC50=12 nM).2 SMED-1 displays strong synergism at 10 μM plus 1 mM Dex and exhibits little activity alone (IC50>20 μM). SMED-1 is Dex-synergistic in ALL-3, ALL-4 and ALL-16 xenografts but is antagonistic with ALL-31. Synergy is highest when drugs are given simultaneously.1
References/Citations
1) Toscan et al. (2014), High-throughput screening of human leukemia xenografts to identify dexamethasone sensitizers; J. Biomol. Screen., 19 1391
2) Liem et al. (2004), Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies; Blood, 103 3905
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
A dexamethasone (Dex) sensitizer. SMED-1 was discovered in a screen designed to identify compounds that sensitize Dex-resistant ALL xenografts to Dex.1 The assay employed Dex-resistant ALL-19 cells which are resistant at concentrations up to 850 μM. In contrast ALL-3 cells are sensitive to nanomolar concentrations of Dex (IC50=12 nM).2 SMED-1 displays strong synergism at 10 μM plus 1 mM Dex and exhibits little activity alone (IC50>20 μM). SMED-1 is Dex-synergistic in ALL-3, ALL-4 and ALL-16 xenografts but is antagonistic with ALL-31. Synergy is highest when drugs are given simultaneously.1
References/Citations
1) Toscan et al. (2014), High-throughput screening of human leukemia xenografts to identify dexamethasone sensitizers; J. Biomol. Screen., 19 1391
2) Liem et al. (2004), Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies; Blood, 103 3905
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