SNAP | NO donor

SNAP chemical structure

Available Options

Size:PriceQuantity 
10 mg$40.00
50 mg$180.00
Request Quote / Bulk / Custom Size
Product Inquiry

SNAP (79032-48-7) is a stable S-nitroso compound which can be used as a nitric oxide (NO) donor in biological experiments.  Its half-life for release of NO in aqueous solutions at pH 7 is 5 hours.1 A comprehensive study on its stability in various physiological contexts has been published.2 In the cardiovascular system SNAP induces vasodilation without inducing tolerance (unlike nitroglycerin).3 In cortical neurons it displays a protective effect after serum deprivation.4 It reverses temozolomide resistance in human glioblastoma.5  It is a useful agent for studying physiological and pharmacological actions of nitric oxide.

References/Citations:

  1. Roy et al. (1994), New thionitrites: Synthesis, stability, and nitric oxide generation; J. Org. Chem. 59 7019
  2. Fan et al. (2025), Comprehensive evaluation of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine stability in biomedical contexts; Nitric Oxide. 158 27
  3. Bauer and Fung (1991), Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure; J. Pharmacol. Exp. Ther. 256 249
  4. Figueroa et al. (2005), SNAP, a NO donor, induces cellular protection only when cortical neurons are submitted to some aggression process; Brain Res. 1034 25
  5. Tsai et al. (2019), SNAP reverses temozolomide resistance in human glioblastoma multiforme cells through down-regulation of MGMT; FASEB J. 33 14171
79302-48-7, SNAP NO donor, SNAP supplier

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

SNAP (79032-48-7) is a stable S-nitroso compound which can be used as a nitric oxide (NO) donor in biological experiments.  Its half-life for release of NO in aqueous solutions at pH 7 is 5 hours.1 A comprehensive study on its stability in various physiological contexts has been published.2 In the cardiovascular system SNAP induces vasodilation without inducing tolerance (unlike nitroglycerin).3 In cortical neurons it displays a protective effect after serum deprivation.4 It reverses temozolomide resistance in human glioblastoma.5  It is a useful agent for studying physiological and pharmacological actions of nitric oxide.

References/Citations:

  1. Roy et al. (1994), New thionitrites: Synthesis, stability, and nitric oxide generation; J. Org. Chem. 59 7019
  2. Fan et al. (2025), Comprehensive evaluation of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine stability in biomedical contexts; Nitric Oxide. 158 27
  3. Bauer and Fung (1991), Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure; J. Pharmacol. Exp. Ther. 256 249
  4. Figueroa et al. (2005), SNAP, a NO donor, induces cellular protection only when cortical neurons are submitted to some aggression process; Brain Res. 1034 25
  5. Tsai et al. (2019), SNAP reverses temozolomide resistance in human glioblastoma multiforme cells through down-regulation of MGMT; FASEB J. 33 14171