SP-600125 | JNK inhibitor

CAS:
129-56-6
Catalog Number:
10-1033
Activity:
JNK inhibitor
Alternate Names:
1,9-Pyrazoloanthrone
Chemical Name:
Anthra[1-9-cd]pyrazol-6(2H)-one
Molecular Weight:
220.23
Molecular Formula:
C14H8N2O
Solubility:
Soluble in DMSO (up to 22 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$55.00
50 mg$180.00

SP-600125 (129-56-6) is a selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50‘s range from 40-90 nM). >300-fold selectivity for JNK as compared to related MAP kinases. Anti-inflammatory activity. SP-600125 inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable and active in vivo.

References/Citations:

1)Bennett et al. (2001), SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase; Proc. Natl. Acad. Sci. USA., 98 13681
2) Rahman et al. (2012), Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis; Brain Res., 1448 117

CAS:
129-56-6
Catalog Number:
10-1033
Activity:
JNK inhibitor
Alternate Names:
1,9-Pyrazoloanthrone
Chemical Name:
Anthra[1-9-cd]pyrazol-6(2H)-one
Molecular Weight:
220.23
Molecular Formula:
C14H8N2O
Solubility:
Soluble in DMSO (up to 22 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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