Size | Price | Quantity | |
---|---|---|---|
5mg | $110.00 | ||
25mg | $395.00 |
Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin. It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2). It impaired recovery of motor function in a mouse model of spinal cord injury.2 Reverses the effects of 14-3-3 agonist Fusicoccin A on neurite outgrowth and regeneration in vitro.3 A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.
References/Citations:
C20H30N8
>98% HPLC
NMR (Conforms)
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Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin. It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2). It impaired recovery of motor function in a mouse model of spinal cord injury.2 Reverses the effects of 14-3-3 agonist Fusicoccin A on neurite outgrowth and regeneration in vitro.3 A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.
References/Citations:
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