Spastazoline | Spastin inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $110.00 | ||
| 25mg | $395.00 |
Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin. It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2). It impaired recovery of motor function in a mouse model of spinal cord injury.2 Reverses the effects of 14-3-3 agonist Fusicoccin A on neurite outgrowth and regeneration in vitro.3 A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.
References/Citations:
- Cupido et al. (2019), Designing a chemical inhibitor for the AAA protein spastin using active site mutations; Nat. Chem. Biol. 15 444
- Yang et al. (2023), Inhibition of spastin impairs motor function recovery after spinal cord injury; Brain Res. Bull. 205 110806
- Liu et al. (2024), 14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention; eLife 12 RP90184
C20H30N8
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin. It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2). It impaired recovery of motor function in a mouse model of spinal cord injury.2 Reverses the effects of 14-3-3 agonist Fusicoccin A on neurite outgrowth and regeneration in vitro.3 A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.
References/Citations:
- Cupido et al. (2019), Designing a chemical inhibitor for the AAA protein spastin using active site mutations; Nat. Chem. Biol. 15 444
- Yang et al. (2023), Inhibition of spastin impairs motor function recovery after spinal cord injury; Brain Res. Bull. 205 110806
- Liu et al. (2024), 14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention; eLife 12 RP90184
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