Sphingosine | PKC inhibitor

CAS:
123-78-4
Catalog Number:
10-2287
Activity:
PKC inhibitor
Chemical Name:
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol
Molecular Weight:
299.5
Molecular Formula:
C18H37NO2
Solubility:
Soluble in DMSO (up to 5 mg/ml, with warming) or in Ethanol (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
20 mg$68.00
100 mg$210.00

Sphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4

References/Citations:

1) Merrill et al., (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds; Biochemistry, 28 3138
2) Ohanian and Ohanian (2001) Sphingolipids in mammalian cell signaling; Cell. Mol. Life Science, 58 2053
3) Ruvolo (2003) Intracellular signal transduction pathways activated by ceramide and its metabolites; Pharm. Res., 47 383
4) Olivier (2002) Sphingosine in apoptosis signaling; Biochim. Biophys. Acta, 1585 153

CAS:
123-78-4
Catalog Number:
10-2287
Activity:
PKC inhibitor
Chemical Name:
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol
Molecular Weight:
299.5
Molecular Formula:
C18H37NO2
Solubility:
Soluble in DMSO (up to 5 mg/ml, with warming) or in Ethanol (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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