Splitomicin | Sirt1 inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $220.00 |
Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae.1 Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA.1 Splitomycin inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome.2 Reverses ischemic preconditioning-induced cardioprotection in a mouse model.3
References/Citations:
1) Bedalov et al. (2001), Identification of a small molecule inhibitor of Sir2p; Proc. Natl. Acad. Sci. USA, 98 15113
2) Biacsi et al. (2008), SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome; PLoS Genet., 4(3) e1000017
3) Nadtochiy et al. (2011), Lysine deacetylation in ischaemic preconditioning: the role of SIRT1; Cardiovasc. Res., 89 643
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae.1 Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA.1 Splitomycin inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome.2 Reverses ischemic preconditioning-induced cardioprotection in a mouse model.3
References/Citations:
1) Bedalov et al. (2001), Identification of a small molecule inhibitor of Sir2p; Proc. Natl. Acad. Sci. USA, 98 15113
2) Biacsi et al. (2008), SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome; PLoS Genet., 4(3) e1000017
3) Nadtochiy et al. (2011), Lysine deacetylation in ischaemic preconditioning: the role of SIRT1; Cardiovasc. Res., 89 643
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