SR1078 | ROR agonist
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 10mg | $70.00 | ||
| 50mg | $225.00 |
SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop.2 SR1078 stimulation of RORα restored clock protein BMAL1 expression and oscillation and blocked MYCN-mediated neuroblastoma growth.3 It reduced repetitive behavior is a mouse model of autism suggesting a potential therapeutic pathway for the disorder.4 SR1078 treatment lead to an increase in p53 levels and increased apoptosis in HepG2 cells.5
References/Citations:
- Wang et al. (2010), Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ; ACS Chem. Biol. 5 1029
- Jiang et al. (2022), The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction; Sci. Transl. Med. 14 eabn3586
- Moreno-Smith et al. (2021), Restoration of the molecular clock is tumor suppressive in neuroblastoma; Nat. Commun. 12 4006
- Wang et al. (2016), Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism; ACS Chem. Neurosci. 7 143
- Wang et al. (2012), Regulation of p53 Stability and Apoptosis by an ROR Agonist; PLoS One 7 e34921
C17H10F9NO2
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SR1078 (1246525-60-9) is an agonist of the orphan nuclear receptors RORα and RORγ.1 It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop.2 SR1078 stimulation of RORα restored clock protein BMAL1 expression and oscillation and blocked MYCN-mediated neuroblastoma growth.3 It reduced repetitive behavior is a mouse model of autism suggesting a potential therapeutic pathway for the disorder.4 SR1078 treatment lead to an increase in p53 levels and increased apoptosis in HepG2 cells.5
References/Citations:
- Wang et al. (2010), Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ; ACS Chem. Biol. 5 1029
- Jiang et al. (2022), The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction; Sci. Transl. Med. 14 eabn3586
- Moreno-Smith et al. (2021), Restoration of the molecular clock is tumor suppressive in neuroblastoma; Nat. Commun. 12 4006
- Wang et al. (2016), Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism; ACS Chem. Neurosci. 7 143
- Wang et al. (2012), Regulation of p53 Stability and Apoptosis by an ROR Agonist; PLoS One 7 e34921
Related products
-
DO264 | ABHD12 inhibitor
From $70.00CAS:2301866-59-9Catalog Number:10-3712Activity:ABHD12 inhibitorChemical Name:1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethyl)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thioureaMolecular Weight:542.40Molecular Formula:C23H20Cl2F3N5OSSolubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
iCRT5 | Beta-catenin inhibitor
From $57.00CAS:18623-44-4Catalog Number:10-1371Activity:Beta-catenin inhibitorChemical Name:4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acidMolecular Weight:367.44Molecular Formula:C16H17NO5S2Solubility:Soluble in DMSO (up to 30 mg/ml)Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.Shipping Code:RT -
Elafibranor | PPARalpha/delta agonist
From $65.00CAS:923978-27-2Catalog Number:10-3901Activity:PPARalpha/delta agonistChemical Name:2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acidAlternate Name:GFT505Molecular Weight:384.49Molecular Formula:C22H24O4SSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
