SR9243 | LXR inverse agonist
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $45.00 | ||
| 25 mg | $175.00 |
SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types including SW620 (IC50 = 40 nM), HT-29 (IC50 = 104 nM), DU-145 (IC50 = 15 nM), PC-3 (IC50 = 61 nM), NCI-H23 (IC50 = 72 nM), HOP-62 (IC50 = 26 nM) and MIAPACA-2 (IC50= 18 nM). SR9243 is able to promote apoptotic cancer cell death without adversely affecting non-malignant cells.
References/Citations:
1) Flaveny et al. (2015), Broad anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis; Cancer Cell, 28 42
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types including SW620 (IC50 = 40 nM), HT-29 (IC50 = 104 nM), DU-145 (IC50 = 15 nM), PC-3 (IC50 = 61 nM), NCI-H23 (IC50 = 72 nM), HOP-62 (IC50 = 26 nM) and MIAPACA-2 (IC50= 18 nM). SR9243 is able to promote apoptotic cancer cell death without adversely affecting non-malignant cells.
References/Citations:
1) Flaveny et al. (2015), Broad anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis; Cancer Cell, 28 42
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