SSAA09E1 | SARS-CoV viral entry inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $60.00 | ||
| 25 mg | $195.00 |
SSAA09E1 (433212-75-0) is an inhibitor of SARS coronavirus (SARS-CoV) replication by blocking viral entry (EC50=6.7µM). SSAA09E1 was discovered by screening a chemical library for blocking of entry of HIV-1 pseudotyped with SARS-CoV surface glycoprotein S. The compound acts via inhibition of cathepsin L(IC50=5.33 µM), a host protease required for processing of SARS-S during viral entry. Cathepsin B is not inhibited.1 The compound was also shown to inhibit tyrosinase (IC50=0.14 µM).2
References/Citations:
- Adedeji et al., (2013) Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms; J. Virol. 87 8017
- Liu et al., (2008) 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors; Bioorg. Med. Chem. 16 1096
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SSAA09E1 (433212-75-0) is an inhibitor of SARS coronavirus (SARS-CoV) replication by blocking viral entry (EC50=6.7µM). SSAA09E1 was discovered by screening a chemical library for blocking of entry of HIV-1 pseudotyped with SARS-CoV surface glycoprotein S. The compound acts via inhibition of cathepsin L(IC50=5.33 µM), a host protease required for processing of SARS-S during viral entry. Cathepsin B is not inhibited.1 The compound was also shown to inhibit tyrosinase (IC50=0.14 µM).2
References/Citations:
- Adedeji et al., (2013) Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms; J. Virol. 87 8017
- Liu et al., (2008) 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors; Bioorg. Med. Chem. 16 1096
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