ST034307 | Adenylate cyclase 1 inhibitor/analgesic activity
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $250.00 |
ST034307 (133406-29-8) is a novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3 Displays analgesic properties in a mouse model of inflammatory pain.1 A useful tool for exploring the involvement of AC1 in cellular signalling.2
References/Citations:
1) Brust et al. (2017), Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal, 10 eaah5381
2) Jiang et al, (2018), Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell 175 652
3) Watts (2018), Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain; Neuropsychopharmacology 43 215
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ST034307 (133406-29-8) is a novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3 Displays analgesic properties in a mouse model of inflammatory pain.1 A useful tool for exploring the involvement of AC1 in cellular signalling.2
References/Citations:
1) Brust et al. (2017), Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal, 10 eaah5381
2) Jiang et al, (2018), Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell 175 652
3) Watts (2018), Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain; Neuropsychopharmacology 43 215
Related products
-
Cilostazol | PDE3A inhibitor
From $40.00CAS:73963-72-1Catalog Number:10-1131Activity:PDE3A inhibitorChemical Name:6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinoneMolecular Weight:369.46Molecular Formula:C20H27N5O2Solubility:Soluble in DMSO (up to 20 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 monthsShipping Code:RT -
IBMX | PDE inhibitor
From $36.00CAS:28822-58-4Catalog Number:10-1008Activity:PDE inhibitorAlternate Names:3-Isobutyl-1-methylxanthineChemical Name:3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dioneMolecular Weight:222.25Molecular Formula:C10H14N4O2Solubility:Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Cilostamide | PDE3 inhibitor
From $60.00CAS:68550-75-4Catalog Number:10-2584Activity:PDE3 inhibitorAlternate Names:OPC-3689Chemical Name:N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramideMolecular Weight:342.44Molecular Formula:C20H26N2O3Solubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
