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ST-034307 | Adenylate cyclase 1 inhibitor, analgesic activity

ST-034307 (133406-29-8) is a novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM. Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC1.1 It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells.  It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1

References/Citations

1) Brust et al. (2017), Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal, 10 eaah5381

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Focus Biomolecules cell signaling supplier, chemical structure ST-034307 | Adenylate cyclase 1 inhibitor | CAS 133406-29-8

Catalog#  10-1620-0005

$60.00
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CAS:
133406-29-8
Catalog Number:
10-1620
Activity:
Adenylate cyclase 1 inhibitor, analgesic activity
Chemical Name:
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Molecular Weight:
297.95
Molecular Formula:
C10H4Cl4O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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