Stavudine | HIV reverse transcriptase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 200 mg | $52.00 | ||
| 1 g | $170.00 |
Stavudine (3056-17-5) is a thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs).1,2 Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition.3 Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages.4
References/Citations:
- T-S Lin et al. (1987), Potent and selective in vitro activity of 3’-deoxythymidin-2’-ene (3’-deoxy-2’,3’-didehydrothymidine) against human immunodeficiency virus; Biochem. Pharmacol., 36 2713
- Baba et al. (1987), Both 2’,3’-dideoxythymidine and its 2’,3’-unsaturated derivative (2’,3’-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro; Biochem. Biophys. Res. Commun., 142 128
- Fowler et al. (2014), Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity; Science, 346 1000
- La Rosa et al. (2019), Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-ß Autophagy; J. Alzheimer’s Dis., 72 401
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Stavudine (3056-17-5) is a thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs).1,2 Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition.3 Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages.4
References/Citations:
- T-S Lin et al. (1987), Potent and selective in vitro activity of 3’-deoxythymidin-2’-ene (3’-deoxy-2’,3’-didehydrothymidine) against human immunodeficiency virus; Biochem. Pharmacol., 36 2713
- Baba et al. (1987), Both 2’,3’-dideoxythymidine and its 2’,3’-unsaturated derivative (2’,3’-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro; Biochem. Biophys. Res. Commun., 142 128
- Fowler et al. (2014), Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity; Science, 346 1000
- La Rosa et al. (2019), Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-ß Autophagy; J. Alzheimer’s Dis., 72 401
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