STF-083010 | IRE1 inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $170.00 |
STF-083010 (307543-71-1) is a novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress.1-3 It displays significant antimyeloma activity in model human MM xenografts.1 STF-083010 induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer.4 Active in vivo.
References/Citations:
1) Papandreou et al. (2011), Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma; Blood, 117 1311
2) Wang et al. (2012), Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors; Nature Chem. Biol., 8 982
3) Tam et al. (2014), Ire1 has distinct catalytic mechanisms for XBP/HAC1 splicing and RIDD; Cell Rep., 9 850
4) Chien et al. (2014), Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells; Oncotarget, 5 4881
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
STF-083010 (307543-71-1) is a novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress.1-3 It displays significant antimyeloma activity in model human MM xenografts.1 STF-083010 induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer.4 Active in vivo.
References/Citations:
1) Papandreou et al. (2011), Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma; Blood, 117 1311
2) Wang et al. (2012), Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors; Nature Chem. Biol., 8 982
3) Tam et al. (2014), Ire1 has distinct catalytic mechanisms for XBP/HAC1 splicing and RIDD; Cell Rep., 9 850
4) Chien et al. (2014), Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells; Oncotarget, 5 4881
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