STF-118804 | NAMPT inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $70.00 | ||
| 25mg | $280.00 |
STF-118804 (894187-61-2) is a potent and selective next generation inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), inhibiting NAD+ biosynthesis from nicotinamide.1 It reduced the viability of most B-ALL cells with high potency (low nM range), eliminates leukemia stem cells from mouse bone marrow, and induces regression of ALL xenografts.1 It induces apoptosis and reduced neuroblastoma stem cell neurosphere formation in high-risk neuroblastoma cell lines.2 STF-118804 reduces the growth of pancreatic ductal adenocarcinoma cells.3
References/Citations:
- Matheny et al. (2013), Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens; Chem. Biol. 20 1352
- Vallejo et al. (2020), NAMPT Inhibition induces Neuroblastoma Cell Death and Blocks Tumor Growth; Front. Oncol. 12 883318
- Espindola-Netto et al. (2017), Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer; Oncotarget 8 85054
C25H23N3O4S
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
STF-118804 (894187-61-2) is a potent and selective next generation inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), inhibiting NAD+ biosynthesis from nicotinamide.1 It reduced the viability of most B-ALL cells with high potency (low nM range), eliminates leukemia stem cells from mouse bone marrow, and induces regression of ALL xenografts.1 It induces apoptosis and reduced neuroblastoma stem cell neurosphere formation in high-risk neuroblastoma cell lines.2 STF-118804 reduces the growth of pancreatic ductal adenocarcinoma cells.3
References/Citations:
- Matheny et al. (2013), Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens; Chem. Biol. 20 1352
- Vallejo et al. (2020), NAMPT Inhibition induces Neuroblastoma Cell Death and Blocks Tumor Growth; Front. Oncol. 12 883318
- Espindola-Netto et al. (2017), Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer; Oncotarget 8 85054
Related products
-
NU7441 | DNA-PK inhibitor
From $50.00CAS:503468-95-9Catalog Number:10-4810Activity:DNA-PK inhibitorChemical Name:8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-oneAlternate Name:Ku-57788Molecular Weight:413.49Molecular Formula:C25H19NO3SSolubility:Soluble in DMSO (up to 10 mg/ml with warming).Physical Properties:Off-white to beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
SNS-314 mesylate | Aurora kinase inhibitor
From $70.00CAS:1146618-41-8Catalog Number:10-4779Activity:Aurora kinase inhibitorChemical Name:1-(3-Chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea mesylateMolecular Weight:527.04Molecular Formula:C18H15ClN6OS2 • CH3SO3HSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
HPI-1 | Hedgehog pathway inhibitor
From $75.00CAS:599150-20-6 (anhydrous)Catalog Number:10-4522Activity:Hedgehog pathway inhibitorChemical Name:2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylateMolecular Weight:463.52 (anhydrous)Molecular Formula:C27H29NO6 xH20Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
