STF-31 | GLUT1/NAMPT inhibitor
NMR(conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $90.00 | ||
| 50 mg | $375.00 |
STF-31 (724741-75-7) is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 μM)1 and NAMPT3. It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of STF-31 anti-tumor activity has recently been questioned via use of large-scale cancer cell-line profiling.2 This profiling indicated that nicotinamide phosphoribosyltransferase (NAMPT) was in fact the target of STF-31. The inhibition of NAMPT by STF-31 was confirmed via biochemical assay against recombinant NAMPT. The ability of STF-31 to inhibit NAMPT had been previously displayed (IC50 = 19 nM).3 More recent experiments provide evidence that STF-31 has a dual function and inhibits both GLUT1 and NAMPT in a concentration-dependent manner.4
References/Citations:
1) Chan et al. (2011), Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality; Sci. Transl. Med., 3 94ra70
2) Adams et al., (2014), NAMPT is the Cellular Target of STF-31-Like Small-Molecule Probes; ACS Chem. Biol., 9 2447
3) Dragovich et al. (2014), Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphribosyltransferase (NAMPT); Bioorg. Med. Chem. Lett., 24 954
4)Kraus et al. (2018), Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell Oncol.(Dordr) 41 485
NMR(conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
STF-31 (724741-75-7) is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 μM)1 and NAMPT3. It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of STF-31 anti-tumor activity has recently been questioned via use of large-scale cancer cell-line profiling.2 This profiling indicated that nicotinamide phosphoribosyltransferase (NAMPT) was in fact the target of STF-31. The inhibition of NAMPT by STF-31 was confirmed via biochemical assay against recombinant NAMPT. The ability of STF-31 to inhibit NAMPT had been previously displayed (IC50 = 19 nM).3 More recent experiments provide evidence that STF-31 has a dual function and inhibits both GLUT1 and NAMPT in a concentration-dependent manner.4
References/Citations:
1) Chan et al. (2011), Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality; Sci. Transl. Med., 3 94ra70
2) Adams et al., (2014), NAMPT is the Cellular Target of STF-31-Like Small-Molecule Probes; ACS Chem. Biol., 9 2447
3) Dragovich et al. (2014), Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphribosyltransferase (NAMPT); Bioorg. Med. Chem. Lett., 24 954
4)Kraus et al. (2018), Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell Oncol.(Dordr) 41 485
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