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STF-31 | GLUT1/NAMPT inhibitor

STF-31 (724741-75-7) is an inhibitor of glucose transporter 1 (GLUT1; IC50 = 1 μM)1 and NAMPT3. It has been shown to kill renal cell carcinoma cells (the majority of which lack the von Hippel-Lindau suppressor gene) without toxicity to normal cells. The target of STF-31 anti-tumor activity has recently been questioned via use of large-scale cancer cell-line profiling.2 This profiling indicated that nicotinamide phosphoribosyltransferase (NAMPT) was in fact the target of STF-31. The inhibition of NAMPT by STF-31 was confirmed via biochemical assay against recombinant NAMPT. The ability of STF-31 to inhibit NAMPT had been previously displayed (IC50 = 19 nM).3 More recent experiments provide evidence that STF-31 has a dual function and inhibits both GLUT1 and NAMPT is a concentration-dependent manner.4

1) Chan et al. (2011), Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality; Sci. Transl. Med., 3 94ra70
2) Adams et al., (2014), NAMPT is the Cellular Target of STF-31-Like Small-Molecule Probes; ACS Chem. Biol., 9 2447
3) Dragovich et al. (2014), Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphribosyltransferase (NAMPT); Bioorg. Med. Chem. Lett., 24 954
4)Kraus et al. (2018), Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation; Cell Oncol.(Dordr) 41 485

Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-31 | NAMPT inhibitor | CAS 724741-75-7

Catalog#  10-4570

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Catalog Number:
NAMPT inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
98% by HPLC
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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