STING Degrader 2 | STING molecular glue

CAS:
 N/A
Catalog Number:
 10-3939
STING Degrader 2 chemical structure Focus Biomolecules

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5 mg$120.00
25 mg$425.00

STING Degrader 2 is a molecular glue that covalently binds both STING and RNF126 E3 ligase leading to proteasomal degradation.  It displayed sustained STING degradation with faster onset and at lower concentration (3 µM) when compared to the STING PROTAC SP23.

References/Citations:

  1. Nakamura et al. (2024), Development of STING Degrader with double covalent ligands; Bioorg. Med. Chem. Lett. 102 129677
CAS:
N/A
Catalog Number:
10-3939
Activity:
STING molecular glue
Chemical Names:
(E)-N-(4-(4-(4-(4-methoxyphenyl)-4-oxobut-2-enoyl)piperazin-1-yl)phenyl)-5-nitrofuran-2-carboxamide
Molecular Weight:
504.40
Molecular Formula:

C26H24N4O7

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Orange solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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