Streptonigrin | Induces heterochromatin formation
NMR (Conforms)
Streptonigrin (3930-19-6) promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
References/Citations:
- Loyola et al. (2020), Streptonigrin at low concentrations promotes heterochromatin formation; Sci. Rep. 10 3478
- Ambaye et al. (2018), Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells; Biochemistry 57 1807
- Lee et al. (2018), Renal Cell Carcinoma is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition; Cancers (Basel) 10 455
- Sztiller-Sikorska et al. (2014), Natural compounds’ activity against cancer stem0like or fast-cycling melanoma cells; PLoS One 9 e90783
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Streptonigrin (3930-19-6) promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
References/Citations:
- Loyola et al. (2020), Streptonigrin at low concentrations promotes heterochromatin formation; Sci. Rep. 10 3478
- Ambaye et al. (2018), Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells; Biochemistry 57 1807
- Lee et al. (2018), Renal Cell Carcinoma is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition; Cancers (Basel) 10 455
- Sztiller-Sikorska et al. (2014), Natural compounds’ activity against cancer stem0like or fast-cycling melanoma cells; PLoS One 9 e90783
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