Streptozotocin | Diabetes inducer
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 gram | $100.00 | ||
| 5 gram | $450.00 |
Streptozotocin (18883-66-4) is an N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes.1 Alkylates DNA.2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase.3 Selectively induces death of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition.4 Streptozotocin is not a spontaneous NO donor.5
References/Citations:
1) Szkudelski et al. (2001), The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.; Physiol. Res., 50 537
2) Bennett & Pegg (1981), Alkylation of DNA in rat tissues following administration of streptozotocin; Cancer Res., 41 27861
3) Konrad et al. (2001), The potential mechanism of the diabetogenic action of streptozotocin inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase; Biochem. J., 356 Pt 1 31
4) Gao et al. (2000), Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells; Arch. Biochem. Biophys., 383 296
5) Kroncke & Kolb-Bachofen (1996), Streptozotocin is not a spontaneous NO donor.; Free Radic. Res., 24 77
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Streptozotocin (18883-66-4) is an N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes.1 Alkylates DNA.2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase.3 Selectively induces death of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition.4 Streptozotocin is not a spontaneous NO donor.5
References/Citations:
1) Szkudelski et al. (2001), The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.; Physiol. Res., 50 537
2) Bennett & Pegg (1981), Alkylation of DNA in rat tissues following administration of streptozotocin; Cancer Res., 41 27861
3) Konrad et al. (2001), The potential mechanism of the diabetogenic action of streptozotocin inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase; Biochem. J., 356 Pt 1 31
4) Gao et al. (2000), Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells; Arch. Biochem. Biophys., 383 296
5) Kroncke & Kolb-Bachofen (1996), Streptozotocin is not a spontaneous NO donor.; Free Radic. Res., 24 77
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