SU-1498 | VEGFR kinase inhibitor

CAS:
168835-82-3
Catalog Number:
10-2074
Activity:
VEGFR kinase inhibitor
Chemical Name:
(E)-N-(3′-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
Molecular Weight:
390.52
Molecular Formula:
C25H30N2O2
Solubility:
Soluble in DMSO.
Physical Properties:
Pale yellow solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$55.00
25 mg$220.00

SU-1498 (168835-82-3) is a potent, reversible, selective inhibitor of VEGFR-2, also known as Flk-1 (IC50 = 700 nM). Inhibition of VEGFR-2 blocks angiogenesis in both in vitro and in vivo models. Cell permeable.

References/Citations:

1) Cho et al. (2005), Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor; Am. J. Respir. Cell Mol. Biol., 33 622
2) Wang et al. (2002), Interplay between integrins and FLK-1 in shear stress-induced signaling; Am. J. Physiol. Cell Physiol., 283 C1540
3) Strawn et al. (1996), FLK-1 as a target for tumor growth inhibition; Cancer Res., 56 3540

CAS:
168835-82-3
Catalog Number:
10-2074
Activity:
VEGFR kinase inhibitor
Chemical Name:
(E)-N-(3′-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
Molecular Weight:
390.52
Molecular Formula:
C25H30N2O2
Solubility:
Soluble in DMSO.
Physical Properties:
Pale yellow solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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