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SU-5402 | FGFR Phosphorylation inhibitor

SU-5402 (215543-92-3) inhibits FGFR phosphorylation in vitro, in cell culture1, and in mouse tumor cell models2. SU-5402 can suppress ECP induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells via an FGFR3 dependent pathway3.

References/Citations
1) Lee et al. (2013), Interleukin-1β enhances cell migration through AP-κ1 and NF-B pathway dependent FGF2 expression in human corneal endothelial cells; Biol. Cell, epub ahead of print Jan. 18 2013
2) Paterson et al. (2004),
Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma; Br. J. Haematol., 124 595
3) Jin et al. (2012), Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway; Growth Factors, 30 344

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Focus Biomolecules supplier, chemical structure of SU-5402 | FGFR Phosphorylation inhibitor | CAS 215543-92-3

Catalog#  10-2520

$70.00
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CAS:
215543-92-3
Catalog Number:
10-2520
Activity:
FGFR Phosphorylation inhibitor
Alternate Names:
PF-02969207
Chemical Name:
3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid
Molecular Weight:
296.32
Molecular Formula:
C17H16N2O3
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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