Suc-Leu-Leu-Val-Tyr-AMC | Proteasome substrate
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $30.00 | ||
| 5 mg | $80.00 |
Suc-Leu-Leu-Val-Tyr-AMC (94367-21-2) is a fluorogenic substrate for the chymotryptic activity of the 20S proteasome1 and other chymotrypsin-like proteases, as well as calpains2. A commonly used substrate for assaying proteasomal enzymatic activity.3,4 Excitation max.: 360 nm; emission max.: 460 nm.
References/Citations:
1) Stein et al. (1996), Kinetic characterization of the chymotryptic activity of the 20S proteasome; Biochemistry, 35 3899
2) Sasaki et al. (1984), Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates; J. Biol. Chem., 259 12489
3) Hamouda et al. (2014), The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells; Oncotarget, 5 6252
4) Min et al. (2017), USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; J. Neurochem,, 140 826
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Suc-Leu-Leu-Val-Tyr-AMC (94367-21-2) is a fluorogenic substrate for the chymotryptic activity of the 20S proteasome1 and other chymotrypsin-like proteases, as well as calpains2. A commonly used substrate for assaying proteasomal enzymatic activity.3,4 Excitation max.: 360 nm; emission max.: 460 nm.
References/Citations:
1) Stein et al. (1996), Kinetic characterization of the chymotryptic activity of the 20S proteasome; Biochemistry, 35 3899
2) Sasaki et al. (1984), Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates; J. Biol. Chem., 259 12489
3) Hamouda et al. (2014), The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells; Oncotarget, 5 6252
4) Min et al. (2017), USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; J. Neurochem,, 140 826
Related products
-
DAPI | Fluorescent DNA stain
From $45.00CAS:28718-90-3Catalog Number:10-5065Activity:Fluorescent DNA stainChemical Name:4′,6-Diamidino-2-phenylindole, dihydrochloride
Molecular Weight:350.25Molecular Formula:C16H15N5·2HClSolubility:Soluble in DMSO (up to 35 mg/ml) or water (up to 20 mg/ml with warming)Physical Properties:Yellow solidPurity:98% by TLC/HPLC
NMR (Conforms)Storage Temperature:-20°CStability:PROTECT FROM LIGHT! Stable for 2 years as supplied. Solutions in DMSO may be aliquoted and stored at -20°C for up to 3 months.Shipping Code:RT -
JC-1 | Mitochondrial membrane potential probe
From $55.00CAS:3520-43-2Catalog Number:10-1634Activity:Mitochondrial membrane potential probeChemical Name:5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodideMolecular Weight:652.23Molecular Formula:C25H27Cl4IN4Solubility:Soluble in DMSO (20 mg/ml)Physical Properties:Brown solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Store as supplied desiccated at -20°C for up to 2 years from the date of purchase. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Dansylcadaverine | Autophagic vacuole dye
From $30.00CAS:10121-91-2Catalog Number:10-2847Activity:Autophagic vacuole dyeChemical Name:N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamideAlternate Names:Monodansyl cadaverine; MDCMolecular Weight:335.46Molecular Formula:C17H25N3O2SSolubility:Soluble in DMSO (up to 10 mg/ml with warming) or in Methanol (up to 10 mg/ml)Physical Properties:Off-white solidPurity:97% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
