Sulconazole | Antifungal/ Prevents cancer stem cell formation
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 50 mg | $55.00 | ||
| 250 mg | $150.00 |
Sulconazole (61318-91-0) is a broad-spectrum imidazole antifungal used for the treatment of various skin infections. It inhibits the cytochrome P450 isozyme, C-14-alpha demethylase, preventing ergosterol synthesis. Sulconazole inhibited mammosphere formation, reduced NF-kB, and reduced extracellular IL-8 formation in breast cancer cells leading to inhibition of cancer stem cell formation.1 It has a similar effect on glioma stem cells.2
References/Citations:
- Choi et al. (2019), Disruption of the NF-kB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell formation; Cells, 8 1007
- Yoon et al. (2021), A chemical biology approach reveals a dependency of glioblastoma on biotin distribution; Sci. Adv., 7 eabf6033
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Sulconazole (61318-91-0) is a broad-spectrum imidazole antifungal used for the treatment of various skin infections. It inhibits the cytochrome P450 isozyme, C-14-alpha demethylase, preventing ergosterol synthesis. Sulconazole inhibited mammosphere formation, reduced NF-kB, and reduced extracellular IL-8 formation in breast cancer cells leading to inhibition of cancer stem cell formation.1 It has a similar effect on glioma stem cells.2
References/Citations:
- Choi et al. (2019), Disruption of the NF-kB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell formation; Cells, 8 1007
- Yoon et al. (2021), A chemical biology approach reveals a dependency of glioblastoma on biotin distribution; Sci. Adv., 7 eabf6033
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