Sulfopin | Pin1 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $40.00 | ||
| 25 mg | $125.00 |
Sulfopin (2451481-08-4) is a potent and selective covalent inhibitor of peptidyl-prolyl isomerase NIMA interacting-1 (Pin1) (Ki = 17 nM).1 Although it displayed little to no cytotoxicity against a panel of 300 cancer cell lines, it had a significant impact on cancer cell growth after prolonged treatment. It suppressed MYCN-driven neuroblastoma initiation and the growth and survival of primary neuroblastoma tumor cell transplants in zebrafish.
References:
- Dubiella et al. (2021), Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo; Nat. Cham. Biol. 17 954
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Sulfopin (2451481-08-4) is a potent and selective covalent inhibitor of peptidyl-prolyl isomerase NIMA interacting-1 (Pin1) (Ki = 17 nM).1 Although it displayed little to no cytotoxicity against a panel of 300 cancer cell lines, it had a significant impact on cancer cell growth after prolonged treatment. It suppressed MYCN-driven neuroblastoma initiation and the growth and survival of primary neuroblastoma tumor cell transplants in zebrafish.
References:
- Dubiella et al. (2021), Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo; Nat. Cham. Biol. 17 954
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