Sulindac Sulfide | NFkappaB inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $50.00 | ||
| 25 mg | $180.00 |
Sulindac sulfide (49627-27-2) is the active metabolite of cyclooxygenase inhibitor sulindac.1 Strongly inhibits Ras induced malignant transformation and Ras/Raf dependent transactivation.2 Sulindac sulfide induces apoptosis in cancer cells via PDE5 inhibition.3,4 Modulates beta-catenin mediated effects.5
References/Citations:
1) Duggan et al. (1977) Identification of the biologically active form of sulindac; J. Pharmacol. Exp. Ther., 201 8
2) Herrmann et al. (2000) Sulindac sulfide inhibits Ras signaling; Nature 17 1769
3) Tinsley et al. (2010) Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDS is associated with PDE5 inhibition; Cancer Prev. Res., 3 1303
4) Tinsley et al. (2011) Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin mediated transcription in human breast tumor cells; Cancer Prev .Res., 4 1275
5) Bravi et al. (2015) Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice; Proc. Natl. Acad. Sci. USA, 112 8421
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Sulindac sulfide (49627-27-2) is the active metabolite of cyclooxygenase inhibitor sulindac.1 Strongly inhibits Ras induced malignant transformation and Ras/Raf dependent transactivation.2 Sulindac sulfide induces apoptosis in cancer cells via PDE5 inhibition.3,4 Modulates beta-catenin mediated effects.5
References/Citations:
1) Duggan et al. (1977) Identification of the biologically active form of sulindac; J. Pharmacol. Exp. Ther., 201 8
2) Herrmann et al. (2000) Sulindac sulfide inhibits Ras signaling; Nature 17 1769
3) Tinsley et al. (2010) Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDS is associated with PDE5 inhibition; Cancer Prev. Res., 3 1303
4) Tinsley et al. (2011) Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin mediated transcription in human breast tumor cells; Cancer Prev .Res., 4 1275
5) Bravi et al. (2015) Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice; Proc. Natl. Acad. Sci. USA, 112 8421
Related products
-
17-AAG | HSP90 inhibitor
From $35.00CAS:75747-14-7Catalog Number:10-1097Activity:HSP90 inhibitorChemical Name:17-(Allylamino)-17-desmethoxygeldanamycinMolecular Weight:585.7Molecular Formula:C31H43N3O8Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml).Physical Properties:Purple or dark red solidPurity:>98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Troglitazone | PPARgamma agonist
From $86.00CAS:97322-87-7Catalog Number:10-1046Activity:PPARγ agonistChemical Name:(±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]-benzyl]-2,4-thiazolidinedioneMolecular Weight:441.55Molecular Formula:C24H27NO5SSolubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
Sunitinib malate | VEGFR, PDGFR kinase inhibitor
From $60.00CAS:341031-54-7Catalog Number:10-1078Activity:VEGFR, PDGFR kinase inhibitorAlternate Names:SU-11248Chemical Name:N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malateMolecular Weight:532.57Molecular Formula:C22H27FN4O4 C4H6O5Solubility:Soluble in DMSO (up to 13 mg/ml).Physical Properties:Orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
